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- Patients seldom complain of drug use but may present with:
- Depressed mood.
- Nervousness.
- Insomnia.
- Physical complications of drug use.
- Accidents or injuries due to drug use.
- There may also be:
- denial of drug use.
- unexplained change in behaviour, appearance, or functioning
- complaints of pain or direct request for prescriptions for narcotics or other drugs.
- legal and social problems due to drug use(marital problems, missed work).
- Signs of drug withdrawal may be present, i.e.,
- Opiates - nausea, sweating, tremors
- Sedatives - anxiety, tremors, hallucinations ·
- Stimulants - depression, moodiness
- Family may request help before patient presents (e.g. irritable at home, missing work).
- Heavy or frequent use of illicit drugs or sedatives
- Continued use of drugs despite clear physical harm( e.g. injuries while intoxicated) psychological harm (e.g., psychiatric symptoms due to drug use) or harmful social consequences (e.g. loss of job)
- Difficulty controlling drug use.
- Strong desire to use drugs.
- Tolerance (can use large amounts of drugs without appearing intoxicated).
- Withdrawal (anxiety, tremors, or other withdrawal symptoms after stopping use)
- Drug use disorders commonly coexist with alcohol disorders (see Alcohol use disorders).
- Symptoms of anxiety or depression may occur with heavy drug use. If these continue after a period of abstinence (e.g., about four weeks), see sections on Depression, and Generalized Anxiety.

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